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Alzheimer’s Clinical Trials Get A Prevention Makeover

From trial-ready registries to genotyping parties, the field has developed new techniques and meds to stem a tide of failed trials. Alzforum’s 13-part series sums up the state of the art as presented at a recent conference.
18-Dec-2017 8:00 AM EST Add to Favorites

Clinical Trials on Alzheimer’s Disease: Shifting the Focus to Prevention

This past decade, Alzheimer’s science has undergone a paradigm shift toward the disease’s early, silent phase. For trials, this means change at every level: new participants, new screening tools, new outcome measurements. What’s the progress?
11-Dec-2017 8:00 AM EST Add to Favorites

Direct-To-Consumer Genetic Testing Can Be a Trip Down the Rabbit Hole

Anyone can learn whether they carry mutations known to cause Alzheimer’s, frontotemporal dementia, and other fatal neurodegenerative diseases.
12-Jul-2017 8:05 AM EDT Add to Favorites

A Single Microglial Protein Controls Suite of Alzheimer’s Risk Genes

The discovery hints that microglia, rather than neurons, may control much of a person’s genetic susceptibility to Alzheimer’s disease.
19-Jun-2017 11:05 AM EDT Add to Favorites

More Support for Amyloid Hypothesis in Alzheimer's: Protective APP Mutation Lowers Aβ in Blood

A new study shows that people with a protective Aβ mutation have less of the peptide in their blood all through their lives, likely explaining why they do not get Alzheimer's. It suggests ways to prevent the disease in the vast majority of people...
15-Jun-2017 2:05 PM EDT Add to Favorites

Robert Terry, Co-Founder of U.S. Alzheimer’s Research Dies at 93

A founder of U.S. Alzheimer’s research, Robert D. Terry, has died at 93. He first showed what plaques and tangles look like in the electron microscope, and linked failing cognition to withering synapses in the brain.
5-Jun-2017 8:05 AM EDT Add to Favorites

Gel-Like Drops of Protein and RNA Make a Splash in Neurodegenerative Diseases

At a meeting in Leuven, Belgium, a coherent picture began to emerge for how fluid pockets of proteins and RNAs contribute to health and disease.
1-Jun-2017 1:05 PM EDT Add to Favorites

How Do You Tell a Cognitively Normal Person They Will Likely Get Alzheimer’s in the Next Few Years?

As researchers seek cognitively normal people on the way to Alzheimer’s to fill clinical prevention trials, they face the delicate task of disclosing a highly elevated, but not certain, risk of developing the disease to thousands of people....
11-Sep-2016 6:05 PM EDT Add to Favorites

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