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In diseases like cancer, atherosclerosis, and sickle cell anemia, cathepsins promote their propagation. Drug trials to inhibit these enzymes have failed due to baffling side effects. Now a new study examines cathepsins in systems to remove some of the bafflement.

Channels: All Journal News, Grant Funded News, Blood, Cancer, Clinical Trials, Pharmaceuticals, Embargoed Feed - hidden,

Keywords: Cathepsin, cathepsins, Protease, Protease Inhibitor, Protease Inhibitor Drugs, Systems Biology, Cancer, Sickle Cell Anemia, Sickle Cell Anemia Research, Sickle Cell Disease, Breast Cancer, Breast Cancer Metastasis, atheroscleroisis, Cannibalization, Distracting, autodigestion, cathepsin K, cathepsin L, cathepsin S

Channels: Healthcare, Infectious Diseases, Public Health, Respiratory Diseases and Disorders, Vaccines, China News,

Keywords: Coronavirus, Upper Respiratory Infections

A new study estimates that more than 2 million Americans with heart disease have used marijuana, but the cardiovascular effects of the drug are not fully understood.

Channels: Cardiovascular Health, Heart Disease, Marijuana, Smoking, Embargoed Feed - hidden, All Journal News,

Mesenchymal stromal cells from fat tissue and bone marrow are widely used in therapeutic trials for their anti-inflammatory qualities, but new Mayo Clinic research finds that liver cells may be of greater value. The study, published in Liver Transplantation, finds that liver mesenchymal stromal cells have immunoregulatory qualities that make them more effective than similar cells derived from adipose, or fat, tissue and bone marrow.

Channels: Immunology, Kidney Disease, Liver Disease, Transplantation,

Keywords: Mayo Clinic, Immunology, Transplant, Timucin Taner, Liver

It represents an entirely new type of ground state for transition metal oxides, and opens new directions for experiments and theoretical studies of how superconductivity arises and how it can be optimized in this system and possibly in other compounds.

Channels: Energy, Engineering, Materials Science, Physics, Travel and Transportation,

Keywords: SLAC National Accelerator Laboratory, Superconductors, condensed matter physics and materials, X-ray science

A variety of existing drugs for treating conditions such as diabetes, inflammation, alcohol abuse, and arthritis in dogs can also kill cancer cells in the lab, according to a study by scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard.

Channels: All Journal News, Grant Funded News, Cancer, Clinical Trials, Pharmaceuticals, National Institutes of Health (NIH), Nature (journal), Cancer Center Featured Story 2, Embargoed Feed - hidden,

Keywords: Dana-Farber Cancer Institute, Dana-Farber, Broad Institute of MIT and Harvard, drug repurposing

Contrary to long-held beliefs, humans did not make major changes to the landscape prior to European colonization, according to new research conducted in New England featuring faculty at Binghamton University, State University of New York. These new insights into the past could help to inform how landscapes are managed in the future.

Channels: All Journal News, Archaeology and Anthropology, Environmental Science, Embargoed Feed - hidden, Wildlife, Staff Picks, Nature,

Keywords: Native Americans, european colonization, european contact, New England, fire, Forests, Emerson College, Harvard, Harvard University, University of Wyoming , Public Archeology Laboratory, Environment, Native People, Deforestation, Conservation, land conservation, Archaeology, Ecology, Land Use, pre-colonial history, History, forest burning, Sustainability, National Science Foundation, Binghamton, Binghamton University, SUNY Binghamton, State University of New York at Binghamton

Mice given a new drug targeting a key gene involved in lipid and glucose metabolism could tolerate a high-fat diet regimen (composed of 60% fat from lard) without developing significant liver damage, becoming obese, or disrupting their body’s glucose balance.

Channels: Clinical Trials, Liver Disease, Obesity, Pharmaceuticals, Weight Loss, National Institutes of Health (NIH), Grant Funded News,

Keywords: Nash, Liver Cancer

Patient enrollment in clinical trials as the first course of treatment after cancer diagnosis is low, despite the fact that enrollment may increase life expectancy, according to researchers at Penn State.

Channels: Cancer, Clinical Trials, Healthcare, All Journal News,

Keywords: Research, Cancer Research, clinical trial, Cancer Clinical Trials

Despite research showing that aggressive treatment with surgery, chemotherapy and radiation can extend the lives of and even cure patients with advanced bladder cancer, many don’t get it. The result, argues a team led by UC Davis Health urologists, is that the disease for many is still as deadly as it was 30 years ago.

Channels: Cancer, Healthcare, Surgery, Cancer Center Featured Story 2, All Journal News,

Keywords: Bladder Cancer, Urology, urologic oncology, Urologic Cancer