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University Hospitals Seidman Cancer Center treats its first glioblastoma patient with genetically modified poliovirus

University Hospitals Cleveland Medical Center

University Hospitals Seidman Cancer Center treated its first patient in a new clinical trial to validate the groundbreaking effects of the poliovirus on glioblastoma (GBM), a deadly Grade IV cancer of the brain. UH is the only Midwest site participating in this clinical trial, which was initiated at Duke Cancer Institute in Durham, NC. The original study, which ran from 2012-2017, was published in New England Journal of Medicine in July 2018 as well as highlighted on “60 Minutes” in 2015 and again in 2018. The study found that survival rates were significantly higher in glioblastoma patients who received an intratumoral infusion of a modified viral chimera combining the polio and rhinoviruses (PVSRIPO immunotherapy) compared to patients receiving standard treatment at the same institution.

Channels: All Journal News, Cancer, Clinical Trials, Healthcare, Immunology, Neuro, Surgery, NEJM,

Released:
24-Jan-2020 1:00 PM EST
  • Embargo expired:
    24-Jan-2020 12:05 AM EST

Benefits of Fetal Surgery for Spina Bifida Continue Through School Age, National Study Shows

Vanderbilt University Medical Center

The benefits of fetal surgery to repair spina bifida, a procedure pioneered at Vanderbilt University Medical Center (VUMC) in 1997, continue through school age, a National Institutes of Health (NIH) study reports today in the journal Pediatrics.

Channels: All Journal News, Children's Health, Clinical Trials, Healthcare, Neuro, OBGYN, Surgery, National Institutes of Health (NIH),

Released:
23-Jan-2020 12:55 PM EST
Research Results
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Oral Hormone-Blocking Drug May Help with Heavy Menstrual Bleeding

Thomas Jefferson University

In women with uterine fibroids, the drug elagolix suppresses ovarian hormone production and prevents heavy menstrual bleeding

Channels: All Journal News, Clinical Trials, Healthcare, OBGYN, Pharmaceuticals, Surgery, Women's Health, NEJM,

Released:
23-Jan-2020 12:50 PM EST
Research Results
Newswise: Researchers uncover two-drug combo that halts the growth of cancer cells

Researchers uncover two-drug combo that halts the growth of cancer cells

UT Southwestern Medical Center

UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations.

Channels: Cancer, Clinical Trials, Drug Resistance, Healthcare, Pharmaceuticals, National Cancer Institute (NCI), All Journal News,

Released:
23-Jan-2020 12:10 PM EST
Research Results
Embargo will expire:
28-Jan-2020 3:05 AM EST
Released to reporters:
23-Jan-2020 11:50 AM EST

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Research Results
Newswise: Researchers Uncover Mechanism for How Common Gene Therapy Vectors Enter Cells

Researchers Uncover Mechanism for How Common Gene Therapy Vectors Enter Cells

Massachusetts Eye and Ear

Researchers have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types—the most commonly used viral vectors for in vivo gene therapy.

Channels: All Journal News, Cell Biology, Clinical Trials, Genetics, Pharmaceuticals, Vision, National Institutes of Health (NIH),

Released:
23-Jan-2020 11:15 AM EST
Research Results
Newswise: Both simple and advanced imaging can predict best candidates for thrombectomy in stroke patients

Both simple and advanced imaging can predict best candidates for thrombectomy in stroke patients

University of Texas Health Science Center at Houston

Both simple and advanced computed tomography (CT) were effective in accurately predicting which stroke patients would benefit from endovascular thrombectomy to remove a large cerebral clot, but together they were even better, reported researchers at UTHealth in Houston.

Channels: Clinical Trials, Healthcare, Neuro, All Journal News,

Released:
22-Jan-2020 1:25 PM EST
Research Results
Newswise: Community-based counselors help mitigate grief, stress among children orphaned in East Africa

Community-based counselors help mitigate grief, stress among children orphaned in East Africa

University of Washington

A University of Washington-led clinical trial involving more than 600 children in Kenya and Tanzania, in which community members were trained to deliver mental health treatment, showed improvement in participants’ trauma-related symptoms up to a year after receiving therapy.

Channels: Children's Health, Clinical Trials, Mental Health, Psychology and Psychiatry, Trauma, National Institute of Mental Health (NIMH), African News, Healthcare, JAMA, All Journal News,

Released:
22-Jan-2020 12:20 PM EST
Research Results

Social and Behavioral Sciences

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GW Cancer Center Expands Clinical Trial Offerings for Patients with High Risk Cutaneous Squamous Cell Carcinoma

George Washington University

The Cutaneous Oncology Program at the GW Cancer Center was selected as the first global site for a clinical trial for patients with high-risk cutaneous squamous cell carcinoma. The study, sponsored by Regeneron, will examine outcomes for patients treated with Libtayo® (cemiplimab) — an immunotherapy treatment — prior to surgery and radiation therapy.

Channels: Cancer, Clinical Trials, Dermatology,

Released:
22-Jan-2020 9:00 AM EST
Research Results

Clinical Trial: Vitamin D Supplementation Linked to Potential Improvements in Blood Pressure in Children

Health Sciences at the University of Pittsburgh

Overweight and obese vitamin D-deficient children who took a relatively high dose of vitamin D every day for six months had lower blood pressure and improved insulin sensitivity than their peers who took a lower dose, according to the results of a new clinical trial.

Channels: Cardiovascular Health, Children's Health, Clinical Trials, Diabetes, Obesity, Pharmaceuticals, National Institutes of Health (NIH), All Journal News, Grant Funded News,

Released:
21-Jan-2020 11:05 AM EST
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