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Journal of Experimental Medicine

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Newswise: Birth defects associated with Zika virus infection may depend on mother’s immune response, study suggests
  • Embargo expired:
    14-Aug-2019 9:00 AM EDT

Article ID: 717066

Birth defects associated with Zika virus infection may depend on mother’s immune response, study suggests

The Rockefeller University Press

New research led by scientists at The Rockefeller University in New York may help explain why Zika virus infection causes birth defects in some children but not others. The study, which will be published August 14 in the Journal of Experimental Medicine, suggests that the risk of developing an abnormally small head (microcephaly) depends on the types of antibody produced by pregnant mothers in response to Zika infection.

Released:
7-Aug-2019 8:05 AM EDT
Newswise: Precision Editing of Gut Bacteria Reduces Cancer in Mice

Article ID: 716759

Precision Editing of Gut Bacteria Reduces Cancer in Mice

UT Southwestern Medical Center

UT Southwestern researchers have shown that precision editing of the bacterial populations in the gut reduces inflammation-associated colorectal cancer in mice.

Released:
31-Jul-2019 5:00 PM EDT
Newswise: To kill tumors, activate this elite group of T cells

Article ID: 714769

To kill tumors, activate this elite group of T cells

La Jolla Institute for Immunology

Tissue-resident memory T cells (TRMs) are known to help the body fight infection, but they are also key tumor fighters. A new study reveals that these cells are unique in their ability to seek out and kill tumor cells without suffering from the common phenomenon of T cell “exhaustion.”

Released:
21-Jun-2019 5:05 PM EDT
Newswise: Researchers find genetic cause for fatal response to Hepatitis A
  • Embargo expired:
    18-Jun-2019 9:00 AM EDT

Article ID: 714272

Researchers find genetic cause for fatal response to Hepatitis A

The Rockefeller University Press

Researchers have identified a genetic mutation that caused an 11-year-old girl to suffer a fatal reaction to infection with the Hepatitis A virus (HAV). The study, which will be published June 18 in the Journal of Experimental Medicine, reveals that mutations in the IL18BP gene causes the body’s immune system to attack and kill healthy liver cells, and suggests that targeting this pathway could prevent the deaths of patients suffering rapid liver failure in response to viral infection.

Released:
12-Jun-2019 9:00 AM EDT
Newswise: Researchers identify human protein that aids development of malaria parasite
  • Embargo expired:
    12-Jun-2019 9:00 AM EDT

Article ID: 713966

Researchers identify human protein that aids development of malaria parasite

The Rockefeller University Press

Researchers in Japan have discovered that the Plasmodium parasites responsible for malaria rely on a human liver cell protein for their development into a form capable of infecting red blood cells and causing disease. The study, which will be published June 12 in the Journal of Experimental Medicine, suggests that targeting this human protein, known as CXCR4, could be a way to block the parasite’s life cycle and prevent the development of malaria.

Released:
5-Jun-2019 10:05 AM EDT
Newswise: Researchers identify new roles for common oncogene MYC
  • Embargo expired:
    29-May-2019 9:00 AM EDT

Article ID: 713305

Researchers identify new roles for common oncogene MYC

The Rockefeller University Press

Cancer researchers have discovered surprising new functions for a protein called MYC, a powerful oncogene that is estimated to drive the development of almost half a million new cancer cases in the US every year. The study, which will be published May 29 in the Journal of Experimental Medicine, shows that MYC affects the efficiency and quality of protein production in lymphoma cells, fueling their rapid growth and altering their susceptibility to immunotherapy.

Released:
22-May-2019 9:25 AM EDT
Newswise: Antibiotic treatment alleviates Alzheimer’s disease symptoms in male mice, study reveals
  • Embargo expired:
    16-May-2019 9:00 AM EDT

Article ID: 712629

Antibiotic treatment alleviates Alzheimer’s disease symptoms in male mice, study reveals

The Rockefeller University Press

Researchers at The University of Chicago have demonstrated that the type of bacteria living in the gut can influence the development of Alzheimer’s disease symptoms in mice. The study, which will be published May 16 in the Journal of Experimental Medicine, shows that, by altering the gut microbiome, long-term antibiotic treatment reduces inflammation and slows the growth of amyloid plaques in the brains of male mice, though the same treatment has no effect on female animals.

Released:
13-May-2019 9:00 AM EDT
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Article ID: 712434

Obesity reprograms immune cells in breasts to promote tumor formation

University of Chicago Medical Center

Macrophages in adipose tissue (fat) link obesity to triple-negative breast cancer. Instead of fighting breast cancer, these immune cells actually promote it.

Released:
6-May-2019 1:05 PM EDT
Newswise: Researchers identify early indicators of pregnancy complications in lupus patients
  • Embargo expired:
    8-Apr-2019 9:00 AM EDT

Article ID: 710761

Researchers identify early indicators of pregnancy complications in lupus patients

The Rockefeller University Press

A study of pregnant women with systemic lupus erythematosus has identified early changes in the RNA molecules present in the blood that could be used to determine the likelihood of them developing preeclampsia. The study, which will be published April 8 in the Journal of Experimental Medicine, may also help researchers develop treatments to prevent other pregnancy complications associated with lupus, including miscarriage and premature birth.

Released:
4-Apr-2019 10:05 AM EDT
Newswise: Researchers discover why men are more likely to develop liver cancer
  • Embargo expired:
    3-Apr-2019 9:00 AM EDT

Article ID: 710311

Researchers discover why men are more likely to develop liver cancer

The Rockefeller University Press

Researchers in Spain have discovered that a hormone secreted by fat cells that is present at higher levels in women can stop liver cells from becoming cancerous. The study, which will be published April 3 in the ournal of Experimental Medicine, helps explain why hepatocellular carcinoma (HCC) is more common in men, and could lead to new treatments for the disease, which is the fourth leading cause of cancer-related death worldwide.

Released:
27-Mar-2019 11:05 AM EDT

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