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Newswise: Scientists discover link between unique brain cells and OCD and anxiety
  • Embargo expired:
    22-Oct-2019 11:00 AM EDT

Article ID: 721142

Scientists discover link between unique brain cells and OCD and anxiety

University of Utah

Scientists discovered a new lineage of specialized brain cells, called Hoxb8-lineage microglia, and established a link between the lineage and OCD and anxiety in mice. Their experiments proved that Hoxb8-lineage microglia prevent mice from displaying OCD behaviors and sex hormones drove symptom severity and anxiety.

Released:
22-Oct-2019 10:20 AM EDT

Social and Behavioral Sciences

Article ID: 720944

Scientists unwind mystery behind DNA replication

Cornell University

The molecules of life are twisted. But how those familiar strands in DNA’s double helix manage to replicate without being tangled up has been hard to decipher. A new perspective from Cornell physicists is helping unravel the mystery.

Released:
17-Oct-2019 1:25 PM EDT
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  • Embargo expired:
    15-Oct-2019 11:00 AM EDT

Article ID: 720478

Genetic Differences in the Immune System Shape the Microbiome

University of Chicago

Genetic differences in the immune system shape the collections of bacteria that colonize the digestive system, according to new research by scientists at the University of Chicago.

Released:
9-Oct-2019 4:05 PM EDT
Newswise: Algorithm Personalizes Which Cancer Mutations Are Best Targets for Immunotherapy
  • Embargo expired:
    9-Oct-2019 11:00 AM EDT

Article ID: 720274

Algorithm Personalizes Which Cancer Mutations Are Best Targets for Immunotherapy

Perelman School of Medicine at the University of Pennsylvania

As tumor cells multiply, they often spawn tens of thousands of genetic mutations. Figuring out which ones are the most promising to target with immunotherapy is like finding a few needles in a haystack. Now a new model hand-picks those needles so they can be leveraged in more effective, customized cancer vaccines.

Released:
7-Oct-2019 9:00 AM EDT
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Article ID: 719987

Moffitt Cancer Center Researchers Identify Mechanism Controlling DNA Repair

Moffitt Cancer Center

Moffitt Cancer Center researchers recently identified a new mechanism that controls DNA repair.

Released:
2-Oct-2019 11:10 AM EDT
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Article ID: 719914

High-fructose + high-fat diet damages mitochondria in the liver increasing risk of fatty-liver disease and metabolic syndrome

Joslin Diabetes Center

BOSTON – (October 1, 2019) – Researchers at Joslin Diabetes Center have found that high levels of fructose in the diet inhibit the liver’s ability to properly metabolize fat. This effect is specific to fructose. Indeed, equally high levels of glucose in the diet actually improve the fat-burning function of the liver. This explains why high dietary fructose has more negative health impacts than glucose does, even though they have the same caloric content.

Released:
1-Oct-2019 11:05 AM EDT
Newswise: Engineered killer T cells could provide long-lasting immunity against cancer

Article ID: 719485

Engineered killer T cells could provide long-lasting immunity against cancer

University of California, Los Angeles (UCLA), Health Sciences

In experiments with mice, UCLA researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method, described in the journal Cell Stem Cell, suppressed the growth of multiple types of human tumors that had been transplanted into the animals.

Released:
23-Sep-2019 5:05 PM EDT

Article ID: 719474

Study Suggests New Metabolic Target for Liver Cancer

University of Iowa

Disrupting a metabolic pathway in the liver in a way that creates a more “cancer-like” metabolism actually reduces tumor formation in a mouse model of liver cancer. This surprising finding from a Univ. of Iowa study identifies the mitochondrial pyruvate carrier as a potential target for preventing liver cancer.

Released:
23-Sep-2019 3:50 PM EDT
Newswise: 211252_web.jpg

Article ID: 719355

First glimpse at what ancient Denisovans may have looked like, using DNA methylation data

Cell Press

If you could travel back in time 100,000 years, you'd find yourself living among multiple groups of humans, including anatomically modern humans

Released:
20-Sep-2019 11:05 AM EDT
Newswise: For gut microbes, not all types of fiber are created equal
  • Embargo expired:
    19-Sep-2019 11:00 AM EDT

Article ID: 719064

For gut microbes, not all types of fiber are created equal

Washington University in St. Louis

Certain human gut microbes with links to health thrive when fed specific types of ingredients in dietary fibers, according to a new study from Washington University School of Medicine in St. Louis. The work — conducted in mice colonized with human gut bacteria and using new technologies for measuring nutrient processing — is a step toward developing more nutritious foods based on a strategy of targeted enrichment of key members of gut microbial communities.

Released:
17-Sep-2019 3:05 AM EDT

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