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Medicine

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Melanoma, GPER, Pregnancy, Estrogen, Immunotherapy

Penn Researchers Identify New Treatment Target for Melanoma

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Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a research team from Perelman School of Medicine at the University of Pennsylvania says it may have determined the reason for the melanoma-protective effect.

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3-D Printed Microfibers Could Provide Structure for Artificially Grown Body Part

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Much as a frame provides structural support for a house and the chassis provides strength and shape for a car, a team of Penn State engineers believe they have a way to create the structural framework for growing living tissue using an off-the-shelf 3-D printer.

Medicine

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High Cholesterol, cholesterol management, Penn Medicine, perelman school of medicine , Health Insurance, Prescription Drug Benefit, Cardiology, Cardiovascular Medicine, PCSK9 Inhibitors, Cardiovascular Quality

Insurance Company Requirements Place Heavy Administrative Burden on Physicians Seeking to Prescribe New Cholesterol-Lowering Drugs

A rare glimpse into the prior authorization requirements implemented by public and private insurance providers across the country has found substantial administrative burden for a new class of medications for patients with high cholesterol that places them at high risk for heart attack or stroke. So-called proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are self-injected medications approved for individuals with a genetic condition called familial hypercholesterolemia (FH) and those with atherosclerotic cardiovascular disease (ASCVD) who have high cholesterol despite receiving traditional statin medications and other treatments. Results of the study are published in Circulation: Cardiovascular Quality and Outcomes.

Medicine

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Medical, Simulation, Education, Patient Safety, Clinical Decision Making, Healthcare, Patient Experience

EMS SimulationIQ and Simulaids ALEX Integration Debuting at IMSH

EMS announces strategic partnership with Simulaids, and integration with their new Patient Communication Simulator, ALEX. Designed to see, listen and talk, ALEX is built for the age of artificial intelligence. Combined with SIMULATIONiQ, the powerful learning management system from EMS, the partners bring an unmatched ability to analyze and evaluate medical clinical decision making performance.

Medicine

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Bipolar Disorder, Comorbidity, Predictors, Prospective, Risk Factors

Can Early Symptoms Predict Bipolar Disorder? Evidence Shows Differing Patterns of Risk Factors

Two patterns of antecedent or "prodromal" psychiatric symptoms may help to identify young persons at increased risk of developing bipolar disorder (BD), according to a new analysis in the Harvard Review of Psychiatry. The journal is published by Wolters Kluwer.

Medicine

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BRCA, Breast Cancer, FDA Approval, olaparib, PARP inhibitor, germline mutations, Genetic Mutations, Penn Medicine, perelman school of medicine , abramson cancer center, Women's Health, Clinical Trials For Cancer

Penn Leader on Trials of Olaparib for Treatment of Breast Cancer Available to Comment on FDA Approval

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Medicine

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Past Exposures Shape Immune Response in Pediatric Acute Respiratory Infections

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By analyzing immune cells of children who came to the emergency department with flu symptoms, researchers found that the suite of genes these early-response cells expressed was shaped by factors such as age and previous exposures to viruses. Better understanding how early infections influence long-term immune response has implications for the diagnosis and treatment of young patients who suffer from acute respiratory tract infections.

Medicine

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University of Pennsylvania School of Nursing, Penn Nursing Science, Penn Nursing, Linda Aiken, University of Southampton, nurse staffing levels, Patient Satisfaction

Nurse Staffing Levels Linked to Patient Satisfaction

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Satisfaction with care in hospitals declines when patients believe there are not enough nurses on wards, according to a new study based on the NHS Inpatient Survey published in the BMJ Open.

Medicine

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Mitochondrial Disease, Vitamins And Supplements, nutritional interventions , mitochondrial medicine, Dietary Supplements, preclinical testing, Precision Medicine

Can Vitamins and Dietary Supplements Benefit Patients with Mitochondrial Disease?

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Defects in mitochondria, the tiny structures that power our cells by functioning as biological batteries, cause an array of complex, often life-threatening disorders that can affect any and all organs and systems. In the absence of validated, effective drug treatments, patients with mitochondrial disease often take a variety of vitamins and supplements, substances that are largely unstandardized, unregulated, and unproven. A group of medical experts recommend performing systematic scientific studies to test precise nutritional interventions for patients.

Medicine

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Research, Orthopaedic Residency, Ranking Metrics

JOT Releases Orthopaedic Residency Program Rankings by Research Output

What's the best way to rate the quality and quantity of research produced by orthopaedic surgery residency programs? A new "research impact ranking" provides a more objective approach to assessing and comparing research productivity at US orthopaedic departments, according to a study in the November Journal of Orthopaedic Trauma (JOT), published by Wolters Kluwer.







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