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Beth Israel Deaconess Medical Center, Pier Paolo Pandolfi, Ming Chen

Flipping the Switch: Dietary Fat, Changes in Fat Metabolism May Promote Prostate Cancer Metastasis

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Prostate tumors tend to be what scientists call “indolent” – so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal. In a set of papers out today in the journals Nature Genetics and Nature Communications, researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms that promote metastasis in the mouse model and also implicated the typical Western high-fat diet as a key environmental factor driving metastasis.

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Materials Science, Biomaterial, Chemical Engineering, Hydrogel, hydrogel research, Therapeutics, Tissue Engineering, drug delivery platform, Drug Delivery, Drug Delivery Systems, Biochemistry

Researchers Program Biomaterials with 'Logic Gates' That Release Therapeutics in Response to Environmental Triggers

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Scientists at the University of Washington announced that they have built and tested a new biomaterial-based delivery system — known as a hydrogel — that will encase a desired cargo and dissolve to release its freight only when specific physiological conditions are met.

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Cancer’s Gene-Determined “Immune Landscape” Dictates Progression of Prostate Tumors

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The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

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Cocaine Abuse

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 16-Jan-2018 11:00 AM EST

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Quantum Dot, quantum dot glow, data transmission, perowskite, Opto Electronics, opto-electronic, Research & Technology

Extremely Bright and Fast Light Emission

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A type of quantum dot that has been intensively studied in recent years can reproduce light in every colour and is very bright. An international research team including scientists from Empa has now discovered why this is the case. The quantum dots could someday be used in LEDs.

Medicine

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Melanoma, Immunotherapy, demoplastic melanoma, PD-1, PD-L1, anti PD-1 PDL-1 therapy

Rare Melanoma Type Highly Responsive to Immunotherapy

Desmoplastic melanoma is a rare subtype of melanoma that is commonly found on sun-exposed areas, such as the head and neck, and usually seen in older patients. Treatment is difficult because these tumors are often resistant to chemotherapy and lack actionable mutations commonly found in other types of melanoma that are targeted by specific drugs. However, Moffitt Cancer Center researchers report in the Jan. 10 issue of Nature that patients with desmoplastic melanoma are more responsive to immune-activating anti-PD-1/PD-L1 therapies than previously assumed.

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Basic Energy Sciences, Basic Energy Research, Material Science, Materials Science, materials science engineering, Materials Science & Engineering, Nature Materials, Materials, Ferroelectric, ferroelectric material, Cornell University, Circuitry, Wires, rewritable wires, electric field, electric switches, Conductivity, Upgrade, Sensors, domain wall, domain wal

Rewritable Wires Could Mean No More Obsolete Circuitry

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An electric field switches the conductivity on and off in atomic-scale channels, which could allow for upgrades at will.

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Immunotherapy Highly Effective in Treatment of Rare Skin Cancer, Study Finds

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In a UCLA-led study, more than two-thirds of people with a rare type of melanoma responded positively to treatment with anti-PD-1 immunotherapies.

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Astronomers Peer Into the Lair of a Mysterious Source of Cosmic Radio Bursts

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Using two of the world’s largest radio telescopes, an international team of astronomers has gained new insights into the extreme home of a mysterious source of cosmic radio bursts. The discovery suggests that the source of the radio emission lies near a massive black hole or within an extremely powerful nebula, and may help shed light on what is causing these strange bursts.

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Fast Radio Burst , Astronomy, Cosmos, Light Years, Cornell University

Fast Radio Bursts ‘Twists and Shouts’ Help Scientists Determine Source of Cosmic Blasts

An international group of astronomers has found that the Cornell University-discovered fast radio burst FRB 121102 – a brief, gigantic pulse of radio waves from 3 billion light years away – passes through a veil of magnetized plasma. This causes the cosmic blasts to “shout and twist,” which will help the scientists determine the source.







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