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Immunology

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Medicine

Science

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Drug Discovery, Drug Development, High-throughput screening, CD73 inhibitors, multiplex RF-MSMS Assay, immuno-oncology, laboratory automation

A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities

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A new original research article in SLAS Discovery presents a fast, sensitive, and robust methodology for screening small molecule inhibitors against CD73/Ecto-5’-Nucleotidase, a promising target for developing anti-cancer drugs.

Medicine

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Study Advances Gene Therapy for Glaucoma

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In a study published today in the scientific journal Investigative Ophthalmology and Visual Science, Kaufman and Curtis Brandt, a fellow professor of ophthalmology and visual sciences at UW-Madison, showed an improved tactic for delivering new genes into the eye's fluid drain, called the trabecular meshwork. It could lead to a treatment for glaucoma.

Medicine

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Cancer, Immunotherapy, PDL1

Who Might Benefit From Immunotherapy? New Study Suggests Possible Marker

New research finds that PDL-1 expressed in antigen presenting cells – macrophages and dendritic cells found in the tumor microenvironment and in the nearby lymph nodes -- is a better indicator than PDL-1 in the tumor of who will respond to immunotherapy drugs.

Medicine

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West Nile Encephalitis, West Nile Virus, Memory

Memory Loss From West Nile Virus May Be Preventable

People who survive brain infection with West Nile virus can have neurological problems long after the virus is gone. A new study in mice suggests that such ongoing problems may be due to unresolved inflammation that hinders the brain's ability to repair damaged neurons and grow new ones. Reducing inflammation with an arthritis drug protected mice from West Nile-induced memory loss.

Medicine

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Melanoma, Cancer, Drug Resistance, Dendritic Cells

Researchers Identify New Way to Unmask Melanoma Cells to the Immune System

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A research team at the Duke Cancer Institute has found a new way to keep the immune system engaged, and is planning to test the approach in a phase 1 clinical trial.

Medicine

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Melanoma, GPER, Pregnancy, Estrogen, Immunotherapy

Penn Researchers Identify New Treatment Target for Melanoma

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Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a research team from Perelman School of Medicine at the University of Pennsylvania says it may have determined the reason for the melanoma-protective effect.

Medicine

Science

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cancer immunotherapy, mechanogenetics, CAR-T cell therapy, Ultrasound

Researchers Develop a Remote-Controlled Cancer Immunotherapy System

A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

Medicine

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Cancer’s Gene-Determined “Immune Landscape” Dictates Progression of Prostate Tumors

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The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

Medicine

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Multiple Sclerosis (MS), Myelin, Demyelination, Pet Scans, remyelination, Positron Emission Tomography

An Innovative PET Tracer Can Measure Damage From Multiple Sclerosis in Mouse Models

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In the January 12, 2017 Scientific Reports, a research team describes early tests of a minimally-invasive way to assess myelin damage—the hallmark of multiple sclerosis—using positron emission tomography (PET). This approach could be used to follow MS lesions over time.

Medicine

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Malaria, Infectious Disease, Genetics, Pharmacology, Whole Genome Analysis, Chemogenetics

Researchers Map Druggable Genomic Targets in Evolving Malaria Parasite

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Researchers at University of California San Diego School of Medicine, with colleagues across the country and around the world, have used whole genome analyses and chemogenetics to identify new drug targets and resistance genes in 262 parasite cell lines of Plasmodium falciparum — protozoan pathogens that cause malaria — that are resistant to 37 diverse antimalarial compounds.







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