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Medicine

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Cancer, Immunotherapy, Cancer Immunity

How a Poorly Explored Immune Cell May Impact Cancer Immunity and Immunotherapy

The immune cells that are trained to fight off the body’s invaders can become defective. It’s what allows cancer to develop. So most research has targeted these co-called effector T-cells. But a new study takes a step back and considers: What if the problem isn’t with the effector T-cells but starts higher up the cellular chain?

Medicine

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Beth Israel Deaconess Medical Center

Like a Baby: The Vicious Cycle of Childhood Obesity and Snoring

Poor nutrition and lack of exercise lead to the increasing prevalence of obesity which, in turn, is the major predictor of diabetes and future risk of cardiovascular disease in western societies. Excess weight is also closely associated with obstructive sleep apnea (OSA), the increasingly common and potentially serious sleep disorder that is often marked by loud snoring. OSA affects about 5 to 10 percent of children 8 to 11 years old. While evidence suggests that OSA appears to exacerbate obesity and its comorbidities such as diabetes and cardiovascular disease, its effects on children have not yet been studied in detail.

Medicine

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Infectious Disease, zika, Virology, Malaria, Public Health, Birth Defects, Chloroquine, Parasitology, Developmental/Reproductive Biology, Disease In The Developing World, Infectious/Emerging Diseases, preclinical research

Anti-Malaria Drug Shows Promise as Zika Virus Treatment

California researchers have discovered that a medication used to prevent and treat malaria may also be effective for Zika virus. The drug, called chloroquine, has a long history of safe use during pregnancy, and is relatively inexpensive. The research was published today in Scientific Reports.

Life

Social and Behavioral Sciences

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Youth, Youth Violence, Social Determinants, violent crime rates, Kansas City, Kansas, Wyandotte County

KU Grant to Examine Comprehensive Approach to Preventing Youth Violence in KC

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A four-year, $1.7 million U.S. Health & Human Services grant will examine the effect of the combined support of multiple organizations and agencies on the same group of youth to prevent violence in Kansas City, Kansas.

Medicine

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Case Western Reserve School of Medicine, Case Comprehensive Cancer Center, Oncogene, Obstetrics, Gynecology, University Hospitals, Cancer Cells, Drugs, epithelial ovarian cancer, Cancer Deaths, Women, DrugPredict, FDA-approved drugs, Aspirin, Nsaids, Ovarian Cancer, drug re-positioning, analisa difeo, rong xu, anil belur nagaraj, Pain Medications

Computer Program Finds New Uses for Old Drugs

Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy. In a recent study published in Oncogene, the researchers successfully translated DrugPredict results into the laboratory, and showed common pain medications—like aspirin—can kill patient-derived epithelial ovarian cancer cells.

Medicine

Science

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Pesticides, Aging, Parkinson Disease, Neurodegeneration

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 21-Nov-2017 12:00 PM EST

Medicine

Science

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Palm Beach, drug, Overdose, Addiction

New Painkillers Reduce Overdose Risk

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The research shows that a range of compounds can deliver pain-blocking potency without affecting respiration.

Science

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Astronomy, Exoplanet, Solar System, Milky Way, Sloan Digital Sky Survey

Vanderbilt Astronomers Continue International Effort to Map and Analyze Universe in Greater Detail Than Ever

Vanderbilt astronomers will join the 5th generation of the Sloan Digital Sky Survey to study nearby solar systems with the potential to harbor life

Medicine

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Biostatistics, Epidemiology, Public Health

Birthing New Findings

A team led by Penn Medicine’s Mary Regina Boland, PhD, an assistant professor of Informatics in Biostatistics, Epidemiology and Informatics, looked at previously documented associations between specific diseases and being born at a certain time of the year, probing deeper to pinpoint the links between them.

Medicine

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Northwestern University, Amish, Genetics, Aging, Youth, Brain

Why These Amish Live Longer and Healthier: An Internal ‘Fountain of Youth’

The first genetic mutation that appears to protect against multiple aspects of biological aging in humans has been discovered in an extended family of Old Order Amish living in the vicinity of Berne, Indiana, report Northwestern Medicine scientists. An experimental “longevity” drug that recreates the effect of the mutation is now being tested in human trials to see if it provides protection against some aging-related illnesses.







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