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Medicine

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Melanoma, GPER, Pregnancy, Estrogen, Immunotherapy

Penn Researchers Identify New Treatment Target for Melanoma

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Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a research team from Perelman School of Medicine at the University of Pennsylvania says it may have determined the reason for the melanoma-protective effect.

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Science

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cancer immunotherapy, mechanogenetics, CAR-T cell therapy, Ultrasound

Researchers Develop a Remote-Controlled Cancer Immunotherapy System

A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

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Beth Israel Deaconess Medical Center, Pier Paolo Pandolfi, Ming Chen

Flipping the Switch: Dietary Fat, Changes in Fat Metabolism May Promote Prostate Cancer Metastasis

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Prostate tumors tend to be what scientists call “indolent” – so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal. In a set of papers out today in the journals Nature Genetics and Nature Communications, researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms that promote metastasis in the mouse model and also implicated the typical Western high-fat diet as a key environmental factor driving metastasis.

Science

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Materials Science, Biomaterial, Chemical Engineering, Hydrogel, hydrogel research, Therapeutics, Tissue Engineering, drug delivery platform, Drug Delivery, Drug Delivery Systems, Biochemistry

Researchers Program Biomaterials with 'Logic Gates' That Release Therapeutics in Response to Environmental Triggers

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Scientists at the University of Washington announced that they have built and tested a new biomaterial-based delivery system — known as a hydrogel — that will encase a desired cargo and dissolve to release its freight only when specific physiological conditions are met.

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Past Exposures Shape Immune Response in Pediatric Acute Respiratory Infections

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By analyzing immune cells of children who came to the emergency department with flu symptoms, researchers found that the suite of genes these early-response cells expressed was shaped by factors such as age and previous exposures to viruses. Better understanding how early infections influence long-term immune response has implications for the diagnosis and treatment of young patients who suffer from acute respiratory tract infections.

Medicine

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Chronic Pain, Fibromyalgia, neuroscien

Does an Exploding Brain Network Cause Chronic Pain?

New research reports that hyperreactive brain networks could play a part in the hypersensitivity of fibromyalgia.

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Cancer’s Gene-Determined “Immune Landscape” Dictates Progression of Prostate Tumors

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The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

Medicine

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Cancer, Immunotherapy, PDL1

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 16-Jan-2018 4:00 PM EST

Medicine

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Scleroderma, University Of Virginia, UVA, University of Virginia Cancer Center, UVA Cancer Center, NCI-designated cancer centers, Cancer, Karen Ballen, University of Virginia School of Medicine, UVA School of Medicine, autoimmune disorder, Autoimmune Disease, skin, Skin Disorder, skin thickening, skin hardening, New Treatments, Medical Research, treatment f

Scleroderma: Study Suggests Hope for Longer Life for Patients with Rare Autoimmune Disorder

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The approach could represent the first new treatment to improve survival in patients with severe scleroderma in more than four decades.

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Discovery Suggests New Strategy for Attacking High- Profile but Elusive Target in Cancer

A discovery by scientists at Dana-Farber Cancer Institute and University of Texas Southwestern Medical Center presents drug developers with an entirely new tack in targeting one of the most-wanted molecular culprits in cancer.







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