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Medicine

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Brain Cancer, Glioblastoma, Poliovirus therapy, Immuno-therapy

Poliovirus Therapy Induces Immune Responses Against Cancer

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An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body’s own capacity to fight malignancies by activating an inflammation process that counter’s the ability of cancer cells to evade the immune system.

Medicine

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Alzheimer's Disease, APOE, tau, Tauopathy

Newly ID’d Role of Major Alzheimer’s Gene Suggests Possible Therapeutic Target

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A new role has been identified for the major Alzheimer’s risk factor ApoE4, suggesting that targeting the protein may help treat the disease. Researchers at Washington University School of Medicine in St. Louis show that ApoE4 exacerbates the brain damage caused by toxic tangles of a different Alzheimer’s-associated protein: tau. In the absence of ApoE, tau tangles did very little harm to brain cells.

Business

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Malaria, Malaria Drug Resistance

Texas Biomed Scientists part of $11.5 million NIH project aimed at combatting drug resistance in the malaria parasite

Texas Biomedical Research Institute researchers, Dr. Tim Anderson and Dr. Ian Cheeseman, have partnered with researchers at the University of Notre Dame and the Center for Infectious Disease Research in Seattle to pursue studies in drug resistant malaria.

Medicine

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Mtor, mTOR inhibitors, Autophagy, PPT1

Penn Researchers Identify New Target, Develop New Drug for Cancer Therapies

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Opening up a new pathway to fight cancer, researchers at the University of Pennsylvania have found a way to target an enzyme that is crucial to tumor growth while also blocking the mechanism that has made past attempts to target that enzyme resistant to treatment. Researchers were able to use this finding to develop a drug that successfully inhibits tumor growth of melanoma as well as pancreatic and colorectal cancer in mice.

Medicine

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Zachary Kaminsky, Zack Kaminsky, arbs, Alcohol, Cholesterol, Pcsk9

Alcohol Use Affects Levels of Cholesterol Regulator through Epigenetics

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In an analysis of the epigenomes of people and mice, researchers at Johns Hopkins Medicine and the National Institutes of Health report that drinking alcohol may induce changes to a cholesterol-regulating gene.

Medicine

Science

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Liver Disease, Fatty Liver, Environment, Pollution, endocrine-disrupting chemicals, Gastroenterology, Non-alcoholic fatty liver disease

UofL Gastroenterology Researcher Receives $4 Million From NIH for Innovative Liver Research

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UofL gastroenterologist Matthew Cave, M.D., believes that chemicals we breathe, consume or come in contact with in the environment may be contributing to liver disease. He has been awarded $4 million by the NIEHS to explore the effects of environmental chemicals on the liver.

Medicine

Science

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Gulf Long-term Follow-up Study, GuLF STUDY, 2010 Deepwater Horizon oil spill, Cleanup Workers, Heatlh, Health Effects, Dispersants, Corexit EC9500A, Corexit EC9527A, National Institute Of Environmental Health Sciences, Niehs

Gulf Spill Oil Dispersants Associated with Health Symptoms in Cleanup Workers

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Workers who were likely exposed to dispersants while cleaning up the 2010 Deepwater Horizon oil spill experienced a range of health symptoms including cough and wheeze, and skin and eye irritation, according to scientists at the National Institutes of Health (NIH). The study appeared online Sept. 15 in Environmental Health Perspectives and is the first research to examine dispersant-related health symptoms in humans.

Medicine

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Stem Cells Development Regeneration, Bone morphogenetic protein, sensory interneurons, Neurons, spinal cord development, Spinal Cord Injury, Sci Treatment And Recovery, Paralysis, Sensory Neurons, Neuron development, Neuroscience, Embryonic Stem Cell Research, Central Nervous System Injuries, spinal cord injury research

Research Redefines Proteins’ Role in the Development of Spinal Sensory Cells

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A recent study led by Samantha Butler at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA has overturned a common belief about how a certain class of proteins in the spinal cord regulate the formation of nervous system cells—called neurons—during embryonic development.

Medicine

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Health, Medicine, Sleep, Depression

Sleep Deprivation Is an Effective Anti-Depressant for Nearly Half of Depressed Patients

Sleep deprivation – typically administered in controlled, inpatient settings – rapidly reduces symptoms of depression in roughly half of depression patients, according the first meta-analysis on the subject in nearly 30 years, from researchers at the Perelman School of Medicine at the University of Pennsylvania.

Medicine

Science

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Autism, ASD, Autism Spectrum Disorders, Motor Behavior, motor deficits, brain processes, Sensorimotor, motor activity, Brain Anatomy, brain mechanisms, Motor Skills

$2.3m Grant to Fund New Direction in Autism Spectrum Disorders Research at KU

Study will define motor deficits in autism spectrum disorders from childhood through adulthood. The long-term goal to learn about the causes of both motor and related behavioral issues to develop more objective, biologically based targets for treatment.







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