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Newswise: Mapping the pathway to gut health in HIV patients

Mapping the pathway to gut health in HIV patients

UC Davis Health

A UC Davis study found that Lactobacillus plantarum bacteria rapidly repaired damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus. It linked chronically inflamed leaky gut to the loss of PPARα signaling and damage to mitochondria.

Channels: Grant Funded News, All Journal News, AIDS and HIV, Digestive Disorders, Immunology, PNAS,

19-Nov-2019 2:00 PM EST
Newswise: One-two punch drug combination offers hope for pancreatic cancer therapy

One-two punch drug combination offers hope for pancreatic cancer therapy

Sanford Burnham Prebys Medical Discovery Institute

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. U.S. Food and Drug Administration (FDA)–approved versions of the compounds are used today to treat certain leukemias and solid tumors, including melanoma. The study was published in Nature Cell Biology.

Channels: All Journal News, Cancer, Clinical Trials, Pharmaceuticals, Digestive Disorders, Grant Funded News,

18-Nov-2019 11:00 AM EST
Research Results

Self-cannibalizing mitochondria may set the stage for ALS development


Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking.

Channels: All Journal News, Cell Biology, Digestive Disorders, Neuro,

18-Nov-2019 10:05 AM EST
Research Alert

Eliminating Common Bacterial Infection Significantly Decreases Gastric Cancer Risk

Perelman School of Medicine at the University of Pennsylvania

Heliobacter pylori infection, quite common around the world, is linked to gastric cancer. Now, a Penn study shows that successfully wiping out the infection lowers the cancer risk.

Channels: All Journal News, Digestive Disorders,

13-Nov-2019 5:05 PM EST
Research Results
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    9-Nov-2019 4:30 PM EST

Babies Exposed to TNF Inhibitors or Tofacitinib in Utero Experience Very Few Serious Infections

American College of Rheumatology (ACR)

A new study found that very few serious infections were seen in children born to mothers with chronic inflammatory diseases who used non-TNFi biologics or tofacitinib during pregnancy compared to children not exposed to these drugs and children exposed to TNFi biologics in utero. These findings are being presented this week at the 2019 ACR/ARP Annual Meeting (Abstract #1901).

Channels: Children's Health, Digestive Disorders, Genetics, OBGYN, Pharmaceuticals, All Journal News, Medical Meetings, Autoimmune Diseases,

6-Nov-2019 12:00 PM EST
Research Results

Adverse Reactions Increase in Children with Use of Common Reflux Aids: Study

Vanderbilt University Medical Center

Proton Pump Inhibitors (PPIs) — such as Prilosec, Protonix and Nexium, have long been one of the most prescribed medications in the country to aid in the reduction of stomach acid. f

Channels: All Journal News, Children's Health, Digestive Disorders,

7-Nov-2019 9:35 AM EST
Research Results

Three-drug combo improves lung function in most common genetic form of cystic fibrosis

UT Southwestern Medical Center

A phase three clinical trial that UT Southwestern participated in determined that a three-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease.

Channels: All Journal News, Children's Health, Clinical Trials, Digestive Disorders, Genetics, Pharmaceuticals, Respiratory Diseases and Disorders, NEJM,

31-Oct-2019 4:55 PM EDT
Research Alert

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