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Autism, Wnt genes, Wnt Pathway, Progenitor Cells, Neuroscience

Faulty Cell Signaling Derails Cerebral Cortex Development, Could It Lead to Autism?

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Eva Anton’s lab at UNC has shown how the deletion of the protein APC in progenitor cells – which give rise to neurons – disrupts the Wnt protein pathway, which previously was linked to genes associated with autism.

Medicine

Science

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Biophysics, Cancer, Drug Discovery, Titan, molecular dyanmaics, Molecular Dynamics

Titan Helps Researchers Suck Mystery Out of Cell’s ‘Vacuum Cleaners’

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In cancer cells, a membrane transport protein called P-glycoprotein, or Pgp, actively pumps anticancer drugs out of the cell, contributing to multidrug resistance. Recently, a team led by computational biophysicist Emad Tajkhorshid from the University of Illinois at Urbana-Champaign (UIUC) used the Titan supercomputer to uncover new details about Pgp that could help the drug discovery community manipulate Pgp function.

Medicine

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Brain Cancer, Glioblastoma, Poliovirus therapy, Immuno-therapy

Poliovirus Therapy Induces Immune Responses Against Cancer

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An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body’s own capacity to fight malignancies by activating an inflammation process that counter’s the ability of cancer cells to evade the immune system.

Medicine

Science

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Glycosylation, Stem Cell, Ricin

Glycosylation: Mapping Uncharted Territory

Glycosylation is the most abundant protein modification - over half of the proteins in our cells are ‘decorated’ with glycans. These sugar structures alter protein activities in all organisms – from bacteria to human - influencing fundamental processes, like protein folding and transport, cell migration, cell-cell interactions, and immune responses.

Medicine

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Microbiome, human microbiome, Gene, DNA, Cancer, GUT, Vagina, skin

Researchers Identify Millions of New Genes in the Human Microbiome

A new study of the human microbiome has uncovered millions of previously unknown genes from microbial communities in the human gut, skin, mouth, and vaginal microbiome, allowing for new insights into the role these microbes play in human health and disease.

Science

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Epigenetics, Epigenetic mechanisms

$2.375 Million Federal Award to Study Epigenetic Control Systems, Inform Drug Discovery

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Van Andel Research Institute scientist Scott Rothbart, Ph.D., has been awarded a five-year, $2.375 million Maximizing Investigators’ Research Award (MIRA/R35) from the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health that will fuel in-depth, multidisciplinary studies into the epigenetic control mechanisms that regulate the genetic code.

Medicine

Science

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gene activation, Genetics, Cell And Developmental Biology, DNA, Leukemia, Lymphoma

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 21-Sep-2017 12:00 PM EDT

Medicine

Science

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melanoma cells, dissemination

Characterization of a Slowly Proliferating Population of Melanoma Cells with High Metastatic Properties

A study conducted at The Wistar Institute has led to the identification of a slowly proliferating and highly invasive melanoma cell subpopulation, characterized by production of a protein associated with invasive behavior.

Medicine

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Immune Cells, Macrophages, Wound Repair, Intestine, Inflammatory Bowel Disease, treatments, Tim Denning, Institute for Biomedical Sciences

Immune Cells Produce Wound Healing Factor, Could Lead To New IBD Treatment

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Specific immune cells have the ability to produce a healing factor that can promote wound repair in the intestine, a finding that could lead to new, potential therapeutic treatments for inflammatory bowel disease (IBD), according to a new research study.

Medicine

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Evolution, Genetics, lncRNAs , Regulatory Gene, Protein Coding, Ulitsky

Genomic Recycling: Ancestral Genes Take On New Roles

Dr. Igor Ulitsky has found that ancient genes that lost their ability to make proteins were “recycled,” surviving across millennia – and species – by evolving to produce a type of RNA that regulates major biological processes. His findings could lead to treatments for a number of genetic diseases.







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