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‘Jumping genes’ help stabilize DNA folding patterns

Washington University in St. Louis

The DNA molecule inside the nucleus of any human cell is more than six feet long. To fit into such a small space, it must fold into precise loops that also govern how genes are turned on or off. New research at Washington University School of Medicine in St. Louis indicates that "jumping genes" play a surprising role in stabilizing the 3D folding patterns of the DNA molecule inside the cell’s nucleus.

Channels: All Journal News, Blood, Cell Biology, Genetics, National Institutes of Health (NIH),

Released:
24-Jan-2020 2:10 PM EST
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Media alert: The Allied Genetics Conference (TAGC) 2020

Genetics Society of America

Reporters are invited to attend The Allied Genetics Conference (TAGC), to be held April 22-26, 2020 in National Harbor, Maryland, just 30 minutes from downtown Washington DC. TAGC 2020 will feature the latest discoveries from researchers at the leading edge of what is possible in the biological and biomedical sciences.

Channels: Aging, Cancer, Cell Biology, Evolution and Darwin, Genetics,

Released:
24-Jan-2020 12:20 PM EST
Research Results
Newswise: Wistar Joins Global Effort to Expedite Coronavirus Vaccine Development for Outbreak Originating in China

Wistar Joins Global Effort to Expedite Coronavirus Vaccine Development for Outbreak Originating in China

Wistar Institute

Wistar announces today that they are part of a team to develop a vaccine against the recently emerged strain of coronavirus (2019-nCoV) that has infected hundreds in China and other countries, including the U.S., and resulted in numerous deaths to date. Wistar is part of a collaboration funded by the Coalition for Epidemic Preparedness Innovations (CEPI).

Channels: Cell Biology, Infectious Diseases, Public Health, China News,

Released:
23-Jan-2020 1:50 PM EST
Announcement
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Liver Fibrosis 'Off Switch' Discovered in Mice

University of California San Diego Health

UC San Diego School of Medicine researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen — providing a new therapeutic target for liver fibrosis.

Channels: Cell Biology, Digestive Disorders, Genetics, Liver Disease, All Journal News,

Released:
23-Jan-2020 1:45 PM EST
Announcement
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Adrenaline Handbrake

Harvard Medical School

Researchers have solved the long-standing mystery of how adrenaline regulates a key class of membrane proteins that are responsible for initiating the contraction of heart cells. The findings provide a mechanistic description of how adrenaline stimulates the heart and present new targets for cardiovascular drug discovery, including the potential development of alternative therapeutics to beta-blockers.

Channels: All Journal News, Cardiovascular Health, Cell Biology, Pharmaceuticals, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Nature (journal),

Released:
23-Jan-2020 12:05 PM EST
Research Results
Newswise: Researchers Uncover Mechanism for How Common Gene Therapy Vectors Enter Cells

Researchers Uncover Mechanism for How Common Gene Therapy Vectors Enter Cells

Massachusetts Eye and Ear

Researchers have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types—the most commonly used viral vectors for in vivo gene therapy.

Channels: All Journal News, Cell Biology, Clinical Trials, Genetics, Pharmaceuticals, Vision, National Institutes of Health (NIH),

Released:
23-Jan-2020 11:15 AM EST
Research Results
Embargo will expire:
30-Jan-2020 11:00 AM EST
Released to reporters:
23-Jan-2020 11:05 AM EST

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Research Results
  • Embargo expired:
    23-Jan-2020 5:00 AM EST

New Drug Target for Prostate Cancer Found in the Non-Coding Genome

University Health Network (UHN)

Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.

Channels: Cancer, Healthcare, Men's Health, Pharmaceuticals, Cell Biology, Genetics, Nature (journal), All Journal News,

Released:
22-Jan-2020 5:55 PM EST
Research Results
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Surprise discovery shakes up our understanding of gene expression

University of Chicago

A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality. Rather than directions going one-way from DNA to RNA to proteins, the latest study shows that RNA itself modulates how DNA is transcribed—using a chemical process that is increasingly apparent to be vital to biology. The discovery has significant implications for our understanding of human disease and drug design.

Channels: Cell Biology, Chemistry, Genetics, Pharmaceuticals, All Journal News,

Released:
22-Jan-2020 2:50 PM EST
Research Results
Newswise: Meet Liguo Wang, Scientific Operations Director of LBMS

Meet Liguo Wang, Scientific Operations Director of LBMS

Brookhaven National Laboratory

This spring, the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory will open its new cryo-electron microscopy (cryo-EM) center, the Laboratory for BioMolecular Structure (LBMS). A state-of-the-art research center for life sciences imaging, LBMS will offer two advanced cryo-electron microscopes for studying complex proteins, as well as the architecture of cells and tissues.

Channels: Cell Biology, DOE Science News, Energy, DOE Science News,

Released:
22-Jan-2020 8:05 AM EST
Research Results


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