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confined spaces, lumen, microtubes, Epithelial Cells, Microfabrication, mechanobiology, epithelial tube

Confined movements: How cells form tubes in confined spaces

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A team of scientists from Singapore and France, led by Professor Lim Chwee Teck, Principal Investigator at the Mechanobiology Institute, Singapore and the Department of Biomedical Engineering at the National University of Singapore, has described a novel ‘microtube’-based platform to study how tubular organs, such as the heart and the kidneys, form under the various topographical restrictions commonly experienced inside the body.

Medicine

Science

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Chromosomes, Genome, Mitosis, Job, Cell Division, Cell Cycle

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 18-Jan-2018 2:00 PM EST

Science

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Seismology, Montreal, Cells, University of Montreal, mechanobiology

Cellular Seismology: Putting Vibrations on the Map

Scientists in Montreal develop a unique technique to map, on a scale of milliseconds, the elasticity of the components inside a cell.

Medicine

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Beth Israel Deaconess Medical Center, Pier Paolo Pandolfi, Ming Chen

Flipping the Switch: Dietary Fat, Changes in Fat Metabolism May Promote Prostate Cancer Metastasis

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Prostate tumors tend to be what scientists call “indolent” – so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal. In a set of papers out today in the journals Nature Genetics and Nature Communications, researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms that promote metastasis in the mouse model and also implicated the typical Western high-fat diet as a key environmental factor driving metastasis.

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Materials Science, Biomaterial, Chemical Engineering, Hydrogel, hydrogel research, Therapeutics, Tissue Engineering, drug delivery platform, Drug Delivery, Drug Delivery Systems, Biochemistry

Researchers Program Biomaterials with 'Logic Gates' That Release Therapeutics in Response to Environmental Triggers

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Scientists at the University of Washington announced that they have built and tested a new biomaterial-based delivery system — known as a hydrogel — that will encase a desired cargo and dissolve to release its freight only when specific physiological conditions are met.

Medicine

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Past Exposures Shape Immune Response in Pediatric Acute Respiratory Infections

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By analyzing immune cells of children who came to the emergency department with flu symptoms, researchers found that the suite of genes these early-response cells expressed was shaped by factors such as age and previous exposures to viruses. Better understanding how early infections influence long-term immune response has implications for the diagnosis and treatment of young patients who suffer from acute respiratory tract infections.

Medicine

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Cancer’s Gene-Determined “Immune Landscape” Dictates Progression of Prostate Tumors

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The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

Medicine

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Scleroderma, University Of Virginia, UVA, University of Virginia Cancer Center, UVA Cancer Center, NCI-designated cancer centers, Cancer, Karen Ballen, University of Virginia School of Medicine, UVA School of Medicine, autoimmune disorder, Autoimmune Disease, skin, Skin Disorder, skin thickening, skin hardening, New Treatments, Medical Research, treatment f

Scleroderma: Study Suggests Hope for Longer Life for Patients with Rare Autoimmune Disorder

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The approach could represent the first new treatment to improve survival in patients with severe scleroderma in more than four decades.

Medicine

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Blood Stem Cell Transplant, bone marrow donor, Bone Marrow Stem Cells, Blood Stem Cells, Blood Stem Cell

Researchers Discover Faster, More Effective Way to Harvest Blood Stem Cells for Bone Marrow Donation

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A multi-institutional research team led by Indiana University School of Medicine scientists has developed a new way to harvest blood stem cells for bone marrow donation that is faster and more effective than the current standard of care.

Medicine

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Alzheimber's Disease, Alzheimer Disease & Associated Disorders, Neurologic Conditions, Parkinson's Disease, Medical Research, Pharmaceticals

Pfizer Announcement on Alzheimer's and Parkinson's Diseases Underscores Need for Government Money for Medical Research.







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