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Alzheimer's and Dementia

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Medicine

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Alzheimer's Disease, APOE, tau, Tauopathy

Newly ID’d Role of Major Alzheimer’s Gene Suggests Possible Therapeutic Target

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A new role has been identified for the major Alzheimer’s risk factor ApoE4, suggesting that targeting the protein may help treat the disease. Researchers at Washington University School of Medicine in St. Louis show that ApoE4 exacerbates the brain damage caused by toxic tangles of a different Alzheimer’s-associated protein: tau. In the absence of ApoE, tau tangles did very little harm to brain cells.

Medicine

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Brain Tumor, Blood Brain Barrier (BBB), Parkinson Disease Treatment, Dementia, Drugs and the Brain

New Model May Help Science Overcome the Brain’s Fortress-Like Barrier

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Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier.

Medicine

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Alzheimber's Disease, Dementia, Research, Conference, Uc Irvine

Addressing the Daily Dilemmas of Dementia Care

On Friday, Sept. 22, UCI MIND and Alzheimer’s Orange County will co-host the 28th Annual Southern California Alzheimer’s Disease Research Conference, themed “The Elephant in the Room: Sensitive Subjects in Dementia Care.” It will highlight “taboo” topics that impact the daily lives of Alzheimer’s patients and their relatives, including elder abuse, end-of-life issues, sex and intimacy, and driving risks.

Science

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Dr. Roberta Diaz Brinton Wins Alzheimer's Drug Discovery Foundation's Melvin R. Goodes Prize

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Dr. Brinton Has Pioneered a Promising Neurogenesis Therapy for Alzheimer's

Medicine

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Alzheimer's, Alzheimer's Disease, Prevention, Vaccine, Clinical Trial, Keck School Of Medicine Of Usc, USC, Lon Schneider, Generation Study, Apoe 4, Amyloid Beta, Clinical Drug Trials, Clinical Drug Development

New Study Investigates Vaccine and Oral Medication to Stop Alzheimer’s Years Before It Begins

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The Keck School of Medicine of USC launches a new study investigating a vaccine and oral medication to stop Alzheimer’s years before it begins

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18th Annual Conference on Alzheimer's Drug Discovery Showcases Non-Amyloid Research

/PRNewswire-USNewswire/ -- Nearly 200 academic and industry researchers came together to share updates on preclinical and clinical-stage Alzheimer's disease research at the 18th Annual Conference on Alzheimer's Drug Discovery. The two-day conference, organized by the Alzheimer's Drug Discovery Foundation (ADDF), is the first and only to focus solely on non-amyloid drug programs in development.

Medicine

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Dementia

Targeting Risk Factors May Prevent Dementia, According to Lancet Commission

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Dementia can potentially be prevented by targeting specific risk factors like education in early life, hearing in midlife, and smoking later in life, according to newly published research by the Lancet Commission on Dementia Prevention, Intervention, and Care. The commission, of which Johns Hopkins School of Nursing(JHSON) faculty member Laura N. Gitlin, PhD, was a member, compiled current research and emerging knowledge about dementia to develop an analysis and plan for moving forward in care.

Medicine

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Alzheimer's Disease, Autism, Obesity, Cardiovascular Disease, Genetic Diseases, Genetics, Cancer, Diabetes, Schizophrenia, Depression, J. Julius Zhu, University Of Virginia, UVA, University of Virginia School of Medicine, Medical Research, Diagnosis., prognostic test, diagnostic tools, prognostic tools, predictive tools, Optical Tweezers, China, Rutgers Univers

Doctors Can Now Predict the Severity of Your Disease by Measuring Molecules

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The simple new technique could offer vastly superior predictions of disease severity in a huge range of conditions with a genetic component, including Alzheimer’s, autism, cancer, cardiovascular disease, diabetes, obesity, schizophrenia and depression.

Medicine

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Ophthalmology, Neurology, FTD, Frontotemporal Dementia, Alzheimer Disease & Associated Disorders, ALS, Lewy Body Dementia, Retina

Eye Changes May Signal Frontotemporal Lobe Degeneration

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Frontotemporal degeneration (FTD) is a progressive neurodegenerative condition that is present in tens of thousands of Americans, but is often difficult to diagnose accurately. Now in a study published this week online ahead of print in Neurology, researchers from the Perelman School of Medicine at the University of Pennsylvania have found evidence that a simple eye exam and retinal imaging test may help improve that accuracy.

Medicine

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Motor Neurons, Neurodegenative Disease, Developmental Biology

Human Skin Cells Transformed Directly Into Motor Neurons

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In new research, scientists at Washington University School of Medicine in St. Louis have converted skin cells from healthy adults directly into motor neurons without going through a stem cell state. The technique makes it possible to study motor neurons of the human central nervous system in the lab. Unlike commonly studied mouse motor neurons, human motor neurons growing in the lab would be a new tool since researchers can’t take samples of these neurons from living people but can easily take skin samples.







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